Objectives:

The course gives a detailed understanding of molecular structure and function of the genetic material in prokaryotic and eukaryotic cells.

Content:

The course deals with; structure of DNA, RNA and chromatin; maintenance of the genome through replication, repair and recombination; expression of the genome through gene regulation, transcription, RNA splicing and translation. Gene technology methods used in studies of biological mechanisms and structures will be presented.

On completion of the course the student should have the following learning outcomes defined in terms of knowledge, skills and general competence:

Knowledge

The student

• can explain DNA structure and topology, RNA structure, chromatin organization and modification with emphasis on function in gene regulation.
• can explain in detail about replication, transcription and translation
• can explain recombination and how DNA damage is created, recognized and repaired
• can explain in detail about molecular mechanisms in gene regulation at all levels
• can compare molecular mechanisms in gene regulation in pro-and eukaryotic organisms
• can update his/her knowledge in molecular biology
• can reflect on ethical issues raised by molecular biology research

Skills

The student

• can communicate knowledge about chromatin and gene regulation
• has the skill to compare molecular mechanisms in gene regulation to show similarities and differences between pro- and eukaryotic organisms
• reads, discusses and communicates relevant scientific literature

Basic knowledge of molecular biology (equivalent to MOL221 and MOL222), molecular cell biology (equivalent to MOL201).

Written exam 4 hours.

Examination support materials: Non